Vision and Mission of the Conference
Our
aim of this one day international level conference to provide a platform for
all the mid career
scientists,
teaching faculties and researchers working in the academics
and industries from all over India to highlight the importance of different types of DNA nano-structure / nano-clues based drug
delivery nano-systems to overcome big obstacles existing in cancer therapy such
as systemic toxicity and unsatisfied drug efficacy. Moreover we review its current clinical status of research.
Objectives:
The
powerful molecular recognition capability of DNA has enabled the controlled
assembly of anisotropic building blocks, leading to multifunctional DNA
nanostructures. Recently, DNA-based
anisotropic, branched, crosslinkable monomers that can carry multiple moieties
on a single molecule with precise control. “DNAsomes”, liposome like core-shell
structures with subunits composed of branched DNA-lipid hybrid molecules.
Unlike traditional liposomes, these DNAsomes can be precisely tuned over a wide
range in terms of both size and surface charge. More importantly, our DNAsome
is a natural carrier of small interfering RNA (si-RNA) due to DNA-RNA
base-pairing, enabling efficient co-delivery of drug and si-RNA to mammalian
cells. The DNAsome represents a universal multifunctional drug vector for
simultaneous delivery of drugs, tracer dyes, or antibodies, along with genes,
si-RNA, or antisense nucleic acids. The following proposed areas to be covered
in this international conference this one day national symposium with a view to
generate mission orient approach:
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Recent advances and reform in self-assembled DNA nanostructures enabled drug
delivery.
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Treatment of cancer via smart DNA nanostructures drug delivery vectors.
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Recent advances in design and fabrication of both static and dynamic
DNA-nanostructures for drug delivery.
►
DNA nanostructures for intelligent drug delivery.
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Nanoclues as molecular transporter in cellular imaging and drug targeting.
►
Current clinical trials status of DNA-nanostructures enabled drug delivery
systems.
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Reform in drug delivery approach in the treatment of cancer.